Hepatitis b virus dna structure

Therapeutic strategies for hepatitis B virus infection: Towards a cure. Drug Discov. Complete and incomplete hepatitis B virus particles: Formation, function, and application. Tsukuda S. Hepatitis B virus biology and life cycle.

Dane D. Virus-like particles in serum of patients with Australia-antigen-associated hepatitis. Luckenbaugh L. Genome-free hepatitis B virion levels in patient sera as a potential marker to monitor response to antiviral therapy.

Viral Hepat. Barrera A. Rabe B. Blondot M. Intracellular transport and egress of hepatitis B virus. Cui X. Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair?

Tang L. Long Q. Kitamura K. Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus. Gerlich W. Guo H. Nassal M. Rall L. Yang W. Integration of hepadnavirus DNA in infected liver: Evidence for a linear precursor. Mason W. Clonal expansion of hepatocytes during chronic woodchuck hepatitis virus infection. Summers J. Residual integrated viral DNA after hepadnavirus clearance by nucleoside analog therapy.

Clonal expansion of normal-appearing human hepatocytes during chronic hepatitis B virus infection. Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis B virus infection. Sung W. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Zhao L. Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma.

Jiang Z. The effects of hepatitis B virus integration into the genomes of hepatocellular carcinoma patients. Genome Res. Zhao K. Dejean A. Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral base-pair direct repeat.

Yan H. Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma. Chauhan R. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinoma. Koch S. Nucleic Acids Res. Shih C.

Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region. Miller R. Hepatitis B virus DNA forms in nuclear and cytoplasmic fractions of infected human liver. Yaginuma K. Hepatitis B virus integration in hepatocellular carcinoma DNA: Duplication of cellular flanking sequences at the integration site. Hino O. Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation. Lau C. Viral-human chimeric transcript predisposes risk to liver cancer development and progression.

Cancer Cell. Budzinska M. Microbes Infect. Mcvey M. MMEJ repair of double-strand breaks: Deleted sequences and alternative endings. Trends Genet. Wang Y. Characterization of HBV integrants in 14 hepatocellular carcinomas: Association of truncated X gene and hepatocellular carcinogenesis.

Tarocchi M. Molecular mechanism of hepatitis B virus-induced hepatocarcinogenesis. Bouchard M. The enigmatic X gene of hepatitis B virus. Akinyemiju T. JAMA Oncol. Hassan M. Risk factors for hepatocellular carcinoma: Synergism of alcohol with viral hepatitis and diabetes mellitus.

Sun C. Incidence and cofactors of hepatitis C virus-related hepatocellular carcinoma: A prospective study of 12, men in Taiwan. Jiang S. Zhong S. Ding D. PLoS Genet. Minami M. Hepatitis B virus-related insertional mutagenesis in chronic hepatitis B patients as an early drastic genetic change leading to hepatocarcinogenesis. Tokino T. Chromosomal sites for hepatitis B virus integration in human hepatocellular carcinoma.

Hepatocyte turnover during resolution of a transient hepadnaviral infection. Feitelson M. Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett. Tang D. Horikawa I. Transcriptional regulation of the telomerase hTERT gene as a target for cellular and viral oncogenic mechanisms. Fujimoto A. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators.

Khoury J. Kawai-Kitahata F. Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological features.

Chiu Y. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Gao Q. Volume Elsevier; Amsterdam, The Netherlands: Ally A. Yoo S. A pilot systematic genomic comparison of recurrence risks of hepatitis B virus-associated hepatocellular carcinoma with low- and high-degree liver fibrosis. BMC Med. Furuta M. Yang L. Tang K. The landscape of viral expression and host gene fusion and adaptation in human cancer.

Dong H. Zhang X. DNA methylation consistency implicates the primary tumor cell origin of recurrent hepatocellular carcinoma. Cao S. Divergent viral presentation among human tumors and adjacent normal tissues. Bayard Q. Bertoli C. Control of cell cycle transcription during G1 and S phases.

Cell Biol. Huang J. Exome sequencing of hepatitis B virus-associated hepatocellular carcinoma. Toh S. Deep sequencing of the hepatitis B virus in hepatocellular carcinoma patients reveals enriched integration events, structural alterations and sequence variations. Hunter T. Cyclins and cancer. Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity. Furler R. Swartling F. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC.

Cao Y. Neuropilin-1 upholds dedifferentiation and propagation phenotypes of renal cell carcinoma cells by activating Akt and sonic hedgehog axes. Cancer Res. Kim Y. Selective down-regulation of glioma-associated oncogene 2 inhibits the proliferation of hepatocellular carcinoma cells. Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells. Zhang D. Expression of glioma-associated oncogene 2 Gli 2 is correlated with poor prognosis in patients with hepatocellular carcinoma undergoing hepatectomy.

Guo C. KMT2D maintains neoplastic cell proliferation and global histone H3 lysine 4 monomethylation. Otsubo T. Microrna inhibits sox2 expression and contributes to gastric carcinogenesis. Wang D. SOX5 promotes epithelial—mesenchymal transition and cell invasion via regulation of Twist1 in hepatocellular carcinoma.

You J. SOX5 promotes cell invasion and metastasis via activation of twist-mediated epithelial— mesenchymal transition in gastric cancer. OncoTargets Ther. Shiraishi Y. Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers. Tamkun J. Plasma fibronectin is synthesized and secreted by hepatocytes. Wang F. Parkin Gene Alterations in Hepatocellular Carcinoma.

Genes Chromosom. Population cytogenetics of folate-sensitive fragile sites—I. Common fragile sites. Stelzer G. The GeneCards suite: From gene data mining to disease genome sequence analyses. Roy A. EMBO J. Tarrini G. GTF2I mutations are common in thymic epithelial tumors but not in hematological malignancies.

Anticancer Res. GTF2I gene mutation—A driver of thymoma pathogenesis. Petrini I. A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors. Higuchi R. Meacci E. Hao N. Cancer Ther. De Waal L.

Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis AH compared to non-alcoholic steatohepatitis NASH : An immunohistochemical analysis of candidate proteins. CHRM3 is a novel prognostic factor of poor prognosis in patients with endometrial carcinoma.

Felton J. Xie G. Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells. Liver Physiol. Chen J. Abstract P Cholinergic receptor muscarinic 3 CHRM3 contributes to breast cancer tumorigenesis through angiogenesis regulation. Yin Q. Muscarinic acetylcholine receptor M1 mediates prostate cancer cell migration and invasion through hedgehog signaling. Asian J.

High expression of M3 muscarinic acetylcholine receptor is a novel biomarker of poor prognostic in patients with non-small cell lung cancer. Tumor Biol. Kodaira M. Functional muscarinic m3 receptor expressed in gastric cancer cells stimulates tyrosine phosphorylation and MAP kinase. Celiktas M. Cancer Inst. Identification of preferred protein interactions by phage-display of the human Src homology-3 proteome.

EMBO Rep. Wang J. A six gene expression signature defines aggressive subtypes and predicts outcome in childhood and adult acute lymphoblastic leukemia. Jia P. Part B Neuropsychiatr.

Lee J. JAMA Neurol. Zhang P. Mao X. The purpose of this study was to investigate the possible relationship between intrauterine infection with and HBV mutations of the genome of the virus.

In this study, HBsAg-positive mothers were divided into two groups: intrauterine infection group and non-infection group according to whether the newborn infants were infected or not. The intrauterine infection group included four pairs of mother and their newborn infants infected in utero, and non-infection group included five HBsAg-positive mothers. Virological and serological assays have been developed for diagnosis of various forms of HBV-associated disease and for treatment of chronic hepatitis B infection.

HBV infection leads to a wide spectrum of liver disease ranging from acute including fulminant hepatic failure to chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Acute HBV infection can be either asymptomatic or present with symptomatic acute hepatitis.